Kirwan House or The Female Orphan House was a female orphanage on Dublin's North Circular Road established in 1791. Destitute Girls (whose both parents were deceased) were placed in the home, and were instructed in the reformed Protestant Christian faith, and were trained to be domestic servants. The Female Orphan House was founded by Mrs. Edward Tighe and Mrs. Margaret Este initially in a small property on Prussia Street but moved to larger premises on North Circular Road, and named after the Dean of Killala, Walter Blake Kirwan, who preached sermons regarding the establishment of such an institution.

Since 1991, it has operated as a Trust Fund to award bursaries to assist in the education of children who were Church of Ireland or of Protestant Churches in Ireland who were in need.